Chromatin Remodeling and Immediate Early Gene Activation by SLFN11 in Response to Replication Stress
Junko Murai, Hongliang Zhang, Lőrinc Sándor Pongor, Sai-Wen Tang, Ukhyun Jo, Fumiya Moribe, Yixiao Ma, Masaru Tomita, Yves Pommier
Abstract
) and GADD45. Both chromatin remodeling and IEG activation require the putative ATPase and helicase activity of SLFN11, whereas canonical extrinsic IEG activation is SLFN11 independent. SLFN11-dependent IEG activation by camptothecin is also observed across 55 non-isogenic NCI-60 cell lines. We conclude that SLFN11 acts as a global regulator of chromatin structure and an intrinsic IEG activator with the potential to engage the innate immune activation in response to replicative stress.
Topics & Concepts
Chromatin remodelingBiologyChromatinCell biologyCellular stress responseActivator (genetics)GeneticsGeneFight-or-flight responseGenomics and Chromatin DynamicsDNA Repair MechanismsPARP inhibition in cancer therapy