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Depletion of SAM leading to loss of heterochromatin drives muscle stem cell ageing

Jengmin Kang, Daniel I. Benjamin, Soochi Kim, Jayesh S. Salvi, G. K. Dhaliwal, Richard Y. Lam, Armon Goshayeshi, Jamie O. Brett, Ling Liu, Thomas A. Rando

2024Nature Metabolism61 citationsDOIOpen Access PDF

Topics & Concepts

HeterochromatinTransmethylationBiologyEpigeneticsAgeingPolyamineCell biologyHistoneSpermidineStem cellIntracellularEZH2MethyltransferaseMethylationBiochemistryGeneticsChromatinDNAGeneEnzymePolyamine Metabolism and ApplicationsEpigenetics and DNA MethylationCancer-related gene regulation
Depletion of SAM leading to loss of heterochromatin drives muscle stem cell ageing | Litcius