Depletion of SAM leading to loss of heterochromatin drives muscle stem cell ageing
Jengmin Kang, Daniel I. Benjamin, Soochi Kim, Jayesh S. Salvi, G. K. Dhaliwal, Richard Y. Lam, Armon Goshayeshi, Jamie O. Brett, Ling Liu, Thomas A. Rando
Topics & Concepts
HeterochromatinTransmethylationBiologyEpigeneticsAgeingPolyamineCell biologyHistoneSpermidineStem cellIntracellularEZH2MethyltransferaseMethylationBiochemistryGeneticsChromatinDNAGeneEnzymePolyamine Metabolism and ApplicationsEpigenetics and DNA MethylationCancer-related gene regulation