Carbon dot incorporated mesoporous silica nanoparticles for targeted cancer therapy and fluorescence imaging
Abolghasem Abbasi Kajani, Laleh Rafiee, Shaghayegh Haghjooy Javanmard, Nasim Dana, Setareh Jandaghian
Abstract
of the functionalized MSNs-CDs. The maximum mortality of 40.66 ± 1.3% of normal HUVEC cells was obtained under the same conditions. Based on the results of flowcytometry analysis, the apoptotic mediated cell death was recognized as the main anticancer mechanism of the MSNs-CDs. The fluorescence imaging of MCF-7 cancer cells was also studied after exposure with MSNs-CDs. The overall results indicated the high potential of the developed nanoplatform for targeted cancer theranostics.
Topics & Concepts
Mesoporous silicaGlutaraldehydeCancer cellNanoparticleFluorescenceNanotechnologyDispersityChemistryMaterials scienceCancerNuclear chemistryMesoporous materialOrganic chemistryCatalysisMedicineInternal medicinePhysicsQuantum mechanicsCarbon and Quantum Dots ApplicationsNanocluster Synthesis and ApplicationsAdvanced Nanomaterials in Catalysis