Borylation of Unactivated C(sp<sup>3</sup>)–H Bonds with Bromide as a Traceless Directing Group
Ge Zhang, Mengyao Li, Wen-Bo Ye, Zhi‐Tao He, Chen‐Guo Feng, Guo‐Qiang Lin
Abstract
A palladium-catalyzed alkyl C-H borylation with bromide as a traceless directing group is described, providing a convenient approach to access alkyl boronates bearing a β-all-carbon quaternary stereocenter. The protocol features a broad substrate scope, excellent site selectivity, and good functional group tolerance.
Topics & Concepts
BorylationChemistryBromideGroup (periodic table)Functional groupMedicinal chemistryCombinatorial chemistryStereochemistryOrganic chemistryArylPolymerAlkylCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsSynthesis and Catalytic Reactions