Dynamic covalent chemistry with azines
Anca‐Elena Dascălu, Lau Halgreen, Aarón Torres‐Huerta, Hennie Valkenier
Abstract
Dynamic covalent chemistry is used in many applications that require both the stability of covalent bonds and the possibility to exchange building blocks. Here we present azines as a dynamic covalent functional group that combines the best characteristics of imines and acylhydrazones. We show that azines are stable in the presence of water and that dynamic combinatorial libraries of azines and aldehydes equilibrate in less than an hour.
Topics & Concepts
Covalent bondDynamic covalent chemistryChemistryGroup (periodic table)Computational chemistryCombinatorial chemistryOrganic chemistryMoleculeSupramolecular chemistryChemical Synthesis and AnalysisSupramolecular Chemistry and ComplexesChemical Reaction Mechanisms