Dual-ligand supramolecular nanofibers inspired by the renin-angiotensin system for the targeting and synergistic therapy of myocardial infarction
Zhanpeng Wen, Jie Zhan, Hekai Li, Guanghui Xu, Shaodan Ma, Jianwu Zhang, Zehua Li, Caiwen Ou, Zhimou Yang, Yanbin Cai, Minsheng Chen
Abstract
A dual-ligand nanoplatform was successfully developed to achieve targeted and synergistic therapy against cardiac deterioration post-MI. We envision that the integration of multiple therapeutic agents through supramolecular self-assembly would offer new insight for the systematic and targeted treatment of cardiovascular diseases.
Topics & Concepts
Myocardial infarctionIn vivoTargeted therapyPharmacologyLigand (biochemistry)ReceptorNanofiberMedicineNanomedicineCancer researchChemistryNanotechnologyInternal medicineMaterials scienceBiologyCancerNanoparticleBiotechnologyPeptidase Inhibition and AnalysisTissue Engineering and Regenerative MedicineElectrospun Nanofibers in Biomedical Applications