IFIT3 Is Increased in Serum from Patients with Chronic Hepatitis B Virus (HBV) Infection and Promotes the Anti-HBV Effect of Interferon Alpha via JAK-STAT2 <i>In Vitro</i>
Siyi Xu, Jinlan Huang, Zhen Xun, Shiqi Li, Ya Fu, Ni Lin, Wennan Wu, Tianbin Chen, Can Liu, Qishui Ou
Abstract
Our study contributes new insights into the understanding of the functions and roles of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3), which is one of the interferon-stimulated genes induced by hepatitis B virus infection in human hepatocytes and hepatocarcinoma cells, and may help to identify targeted genes promoting the efficacy of interferon alpha.
Topics & Concepts
TetratricopeptideInterferonHepatitis B virusSTAT2VirologyAlpha interferonImmunologyIn vitroBiologyVirusGeneHBcAgMedicinestatHBsAgSTAT3GeneticsHepatitis C virus researchHepatitis B Virus StudiesLiver Disease Diagnosis and Treatment