Biodegradable peptide polymers as alternatives to antibiotics used in aquaculture
Pengcheng Ma, Yueming Wu, Weinan Jiang, Ning Shao, Min Zhou, Yuan Chen, Jiayang Xie, Zhongqian Qiao, Runhui Liu
Abstract
therapeutic potential in an adult zebrafish infection model. Moreover, the optimal peptide polymer is biodegradable by enzymes into single amino acids and dipeptides to totally lose its antibacterial activity and, therefore, will not cause antimicrobial selective pressure. Our study suggests that peptide polymers are promising alternatives to antibiotics in aquaculture and open new avenues to address the global challenge of antimicrobial resistance.
Topics & Concepts
AntibioticsPeptideIn vivoAquacultureBiodegradable polymerChemistryBroad spectrumAntibacterial activityIn vitroPolymerCombinatorial chemistryNanotechnologyBiotechnologyBacteriaFish <Actinopterygii>BiochemistryBiologyMaterials scienceOrganic chemistryFisheryGeneticsAntimicrobial Peptides and ActivitiesAntimicrobial agents and applicationsPharmaceutical and Antibiotic Environmental Impacts