Synthesis and Anticancer Activity of a Novel Series of Tetrazolo[1,5-a]quinoline Based 1,2,3-Triazole Derivatives
R. Nagaraju, K. Gopichand, N. Nageswara Rao, Abdul Majeed Ganai, Eslavath Kishan, P. Venkateswar Rao
Abstract
Abstract We report here the synthesis of a novel series of tetrazolo[1,5-a]quinoline based 1,2,3-triazoles from acetaniline via the Vilsmeier–Haack reaction, the Claisen–Schmidt condensation and 1,3-dipolar Click reaction. The newly synthesized compounds have been tested for their anticancer activity against a panel of three cell lines such as cervix (SiHa), brest (MDA-MB-231) and pancreatic carcinoma (PANC-1). Most of the synthesized compounds possess potent anticancer activity.
Topics & Concepts
ChemistryQuinolineClick chemistryCombinatorial chemistryStereochemistryOrganic chemistrySynthesis and biological activityQuinazolinone synthesis and applicationsSynthesis of Tetrazole Derivatives