Mitochondrial Hydrogen Peroxide Activates PTEN and Inactivates Akt Leading to Autophagy Inhibition-Dependent Cell Death in Neuronal Models of Parkinson’s Disease
Qianyun Yu, Ruijie Zhang, Tianjing Li, Yang Liu, Zhihan Zhou, Long Hou, Wen Wu, Rui Zhao, Xiaoling Chen, Yajie Yao, Shile Huang, Long Chen
Topics & Concepts
AutophagyPTENProtein kinase BProgrammed cell deathHydrogen peroxideCell biologyPI3K/AKT/mTOR pathwayMitochondrionApoptosisDiseaseChemistryNeuroscienceBiologyCancer researchSignal transductionBiochemistryMedicineInternal medicineAutophagy in Disease and TherapyParkinson's Disease Mechanisms and TreatmentsRNA regulation and disease