The ABC-Type Efflux Pump MacAB Is Involved in Protection of Serratia marcescens against Aminoglycoside Antibiotics, Polymyxins, and Oxidative Stress
Tatiana V. Shirshikova, Cecilia G. Sierra-Bakhshi, Leisan Kh. Kamaletdinova, Lilia E. Matrosova, Nailya Khabipova, Vladimir G. Evtugyn, Irina V. Khilyas, Iuliia V. Danilova, А. М. Марданова, М. Р. Шарипова, Lydia M. Bogomolnaya
Abstract
The opportunistic pathogen Serratia marcescens can cause urinary tract infections, respiratory infections, meningitis, and sepsis in immunocompromised individuals. These infections are challenging to treat due to the intrinsic resistance of S. marcescens to an extensive array of antibiotics.
Topics & Concepts
Serratia marcescensAntibioticsMicrobiologyColistinEffluxAminoglycosidePolymyxinSepsisMeningitisSerratiaPathogenBiologyMedicineBacteriaImmunologyEscherichia coliGeneticsPseudomonasGeneBiochemistryPsychiatryAntibiotic Resistance in BacteriaVibrio bacteria research studiesAntibiotics Pharmacokinetics and Efficacy