Curcuminoids, a major turmeric component, have a sleep-enhancing effect by targeting the histamine H1 receptor
Min Young Um, Minseok Yoon, Minji Kim, Jonghoon Jung, Seonghui Kim, Dae‐Ok Kim, Suengmok Cho
Abstract
. Furthermore, sleep latency was reduced and NREMS frequency was increased following curcuminoid administration in wild-type mice but not in H1R knockout mice. Therefore, we conclude that curcuminoids reduce sleep latency and enhance the quantity of NREMS by acting as modulators of H1R, indicating their usefulness in treating insomnia.
Topics & Concepts
Histamine H1 receptorHistamineComponent (thermodynamics)PharmacologyChemistrySleep (system call)ReceptorMedicineBiochemistryComputer sciencePhysicsAntagonistThermodynamicsOperating systemCurcumin's Biomedical ApplicationsBiochemical effects in animalsSleep and Wakefulness Research