Novel tryptanthrin derivatives with benzenesulfonamide substituents: Design, synthesis, and anti-inflammatory evaluation
Jiyu Du, Peipei Liu, Yanan Zhu, Guoxing Wang, Siqi Xing, Tongtong Liu, Jucheng Xia, Shuanghong Dong, Na Lv, Zeng Li
Topics & Concepts
p38 mitogen-activated protein kinasesTumor necrosis factor alphaIn vivoChemistryArthritisPharmacologyNitric oxideLipopolysaccharideMAPK/ERK pathwayInflammationWestern blotProinflammatory cytokineSignal transductionImmunologyMedicineBiochemistryBiologyGeneBiotechnologyOrganic chemistryQuinazolinone synthesis and applicationsPeptidase Inhibition and AnalysisSignaling Pathways in Disease