Molecular Mechanisms of the Toll-Like Receptor, STING, MAVS, Inflammasome, and Interferon Pathways
Nathan P. Manes, Aleksandra Nita‐Lazar
Abstract
Pattern recognition receptors (PRRs) form the front line of defense against pathogens. Many of the molecular mechanisms that facilitate PRR signaling have been characterized in detail, which is critical for the development of accurate PRR pathway models at the molecular interaction level. These models could support the development of therapeutics for numerous diseases, including sepsis and COVID-19. This review describes the molecular mechanisms of the principal signaling interactions of the Toll-like receptor, STING, MAVS, and inflammasome pathways. A detailed molecular mechanism network is included as Data Set S1 in the supplemental material.
Topics & Concepts
InflammasomeStingPattern recognition receptorSignal transductionInnate immune systemComputational biologyBiologyMechanism (biology)ReceptorToll-like receptorInterferonCell biologyImmunologyGeneticsEngineeringPhysicsAerospace engineeringQuantum mechanicsinterferon and immune responsesInflammasome and immune disordersImmune Response and Inflammation