LncRNA-mediated cell autophagy: An emerging field in bone destruction in rheumatoid arthritis
Hai-Tao Lei, Jin-Hai Wang, Huijun Yang, H. Felix Wu, Fang-Hong Nian, Fang-Mei Jin, Jing Yang, Xuemei Tian, Haidong Wang
Abstract
In recent years, research on the mechanism of bone destruction in rheumatoid arthritis (RA) has remained in the initial stages, and the mechanism has not been fully elucidated to date. Recent studies have shown that long noncoding RNAs (lncRNAs) participate in RA bone destruction via autophagy, but the specific regulatory mechanism of lncRNA-mediated autophagy is unclear. Therefore, in this article, we review the mechanisms of lncRNA-mediated autophagy in fibroblast-like synoviocytes and chondrocytes in RA bone destruction. We explain that lncRNAs mediate autophagy and participate in many specific pathological processes of RA bone destruction by regulating signalling pathways and the expression of target genes. Specific lncRNAs can be used as markers for molecular diagnosis, mechanistic regulation, treatment and prognosis of RA.