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Novel 1H-pyrazolo[3,4-d]pyrimidin-6-amino derivatives as potent selective Janus kinase 3 (JAK3) inhibitors. Evaluation of their improved effect for the treatment of rheumatoid arthritis

Yuan Yin, Chengjuan Chen, Ru-Nan Yu, Lei Shu, Zhijian Wang, Tiantai Zhang, Dayong Zhang

2020Bioorganic Chemistry21 citationsDOI

Topics & Concepts

ChemistryRheumatoid arthritisJanus kinase 3TofacitinibJanus kinasePharmacologyArthritisKinaseIn vivoBiochemistryIn vitroImmunologyMedicineBiologyBiotechnologyCytotoxic T cellAntigen-presenting cellCytokine Signaling Pathways and InteractionsRheumatoid Arthritis Research and TherapiesMyeloproliferative Neoplasms: Diagnosis and Treatment
Novel 1H-pyrazolo[3,4-d]pyrimidin-6-amino derivatives as potent selective Janus kinase 3 (JAK3) inhibitors. Evaluation of their improved effect for the treatment of rheumatoid arthritis | Litcius