LL-37 transports immunoreactive cGAMP to activate STING signaling and enhance interferon-mediated host antiviral immunity
Xubiao Wei, Lulu Zhang, Yinlong Yang, Yanfei Hou, Yifang Xu, Zhimeng Wang, Huili Su, Fangping Han, Jing Han, Peiyuan Liu, Shuiqing Hu, Matthew D. Koci, Xuxu Sun, Conggang Zhang
Abstract
and sodium butyrate promote host immunity by enhancing endogenous LL-37 expression and its mediated cGAMP immune response. Collectively, our data uncover an essential role of LL-37 in innate immune activation and suggest new strategies for immunotherapy.
Topics & Concepts
StingInterferonStimulator of interferon genesImmunityHost (biology)Innate immune systemCell biologyBiologySignal transductionVirologyImmunologyImmune systemEcologyEngineeringAerospace engineeringinterferon and immune responsesViral Infections and VectorsInflammasome and immune disorders