Overexpression of peroxisome proliferator-activated receptor γ co-activator-1⍺ (PGC-1⍺) in Chinese hamster ovary cells increases oxidative metabolism and IgG productivity
Sarah A. Sacco, Allison G. McAtee Pereira, Irina Trenary, Kevin D. Smith, Michael J. Betenbaugh, Jamey D. Young
Topics & Concepts
Chinese hamster ovary cellCell culturePeroxisomeBiologyOxidative phosphorylationCitric acid cycleMetabolismCell biologyDownregulation and upregulationBiochemistryReceptorGeneGeneticsViral Infectious Diseases and Gene Expression in InsectsMicrobial Metabolic Engineering and BioproductionProtein purification and stability