Novel imidazole derivatives as potential aromatase and monoamine oxidase-B inhibitors against breast cancer
Derya Osmani̇ye, Serkan Levent, Begüm Nurpelin Sağlık, Abdullah Burak Karaduman, Yusuf Özkay, Zafer Asım Kaplancıklı
Abstract
The activity of the synthesized compounds against breast cancer was investigated. Molecular docking studies were performed against aromatase, MAO-B, and Caspase-3 enzymes.
Topics & Concepts
ChemistryAromataseMonoamine oxidaseImidazoleBreast cancerMonoamine oxidase BPharmacologyEnzymeStereochemistryBiochemistryCancerInternal medicineMedicineEstrogen and related hormone effectsBioactive Compounds and Antitumor AgentsSynthesis and biological activity