<i>In Vitro</i> Activity of Cefiderocol, a Siderophore Cephalosporin, against Multidrug-Resistant Gram-Negative Bacteria
Shazad Mushtaq, Zahra Sadouki, Anna Vickers, David M. Livermore, Neil Woodford
Abstract
Cefiderocol is a parenteral siderophore cephalosporin with a catechol-containing 3′ substituent. We evaluated its MICs against Gram-negative bacteria, using iron-depleted Mueller-Hinton broth. The panel comprised 305 isolates of Enterobacterales , 111 of Pseudomonas aeruginosa , and 99 of Acinetobacter baumannii , all selected for carbapenem resistance and multidrug resistance to other agents. At 2 and 4 μg/ml, cefiderocol inhibited 78.
Topics & Concepts
SiderophoreCephalosporinMicrobiologyBiologyGram-negative bacteriaGramBacteriaMultiple drug resistanceIn vitroGram-positive bacteriaAntibioticsEscherichia coliGeneticsGeneAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and EfficacyUrinary Tract Infections Management