Discovery of 4-aminophenylacetamide derivatives as intestine-specific farnesoid X receptor antagonists for the potential treatment of nonalcoholic steatohepatitis
Cong Chen, Bing Zhang, Jiaojiao Tu, Yanfen Peng, Yihuan Zhou, Xinping Yang, Qi-Ming Yu, Xiangduan Tan
Topics & Concepts
Farnesoid X receptorChemistryNonalcoholic steatohepatitisPharmacologySteatosisAntagonistNuclear receptorIC50Internal medicineBiochemistryReceptorEndocrinologyNonalcoholic fatty liver diseaseMedicineFatty liverTranscription factorIn vitroGeneDiseaseDrug Transport and Resistance MechanismsLiver Disease Diagnosis and TreatmentLiver Diseases and Immunity