Impaired macrophage trafficking and increased helper T-cell recruitment with loss of cadherin-11 in atherosclerotic immune response
Camryn Johnson, Lance A. Riley, Matthew R. Bersi, MacRae F. Linton, W. David Merryman
Abstract
Cadherin-11 is well known to contribute to inflammatory and fibrotic disease. Here, we examined its role in atherosclerosis progression, which is predominantly an inflammatory process. We found that while cadherin-11 is associated with plaque progression, global loss of cadherin-11 exacerbated the disease phenotype. Moreover, loss of cadherin-11 in bone marrow-derived immune cells resulted in impaired macrophage migration and an unexplained increase in circulating helper T cells, presumably due to altered macrophage function without cadherin-11.
Topics & Concepts
MacrophageCadherinImmune systemImmunologyInflammationPhenotypeBone marrowBiologyMedicineCellIn vitroGeneGeneticsBiochemistryAtherosclerosis and Cardiovascular DiseasesGalectins and Cancer BiologyCell Adhesion Molecules Research