[Retracted] The Expression of miR‐23a and miR‐146a in the Saliva of Patients with Periodontitis and Its Clinical Significance
Lanhua Kang, Ning Li, Lexiu Wang
Abstract
Background . This study is aimed at exploring the significance of the expression of miR‐23a and miR‐146a in patients with periodontitis and their correlations with inflammatory factors. Methods . A total of 120 patients with chronic periodontitis admitted to the department of stomatology in Yantai Yuhuangding Hospital from August 2017 to December 2018 were enrolled as a study group, and 80 healthy volunteers in physical examination during the same period were enrolled as a control group. The expression of miR‐23a, miR‐146a, interleukin‐1 β (IL‐1 β ), interleukin‐6 (IL‐6), and interleukin‐17 (IL‐17) in the saliva of people in the two groups was determined using the quantitative real‐time polymerase chain reaction (qRT‐PCR) and enzyme‐linked immunosorbent assay (ELISA). Results . The study group showed significantly higher relative expression of saliva miR‐23a and miR‐146a than the control group. The area under the curve (AUC) of saliva miR‐23a and miR‐146a for diagnosing periodontitis was 0.857 and 0.886, respectively. The expression of saliva miR‐23a and miR‐146a increased with the deterioration of periodontitis in the patients. After basic treatment, the study group showed significantly decreased expression of saliva miR‐23a and miR‐146a. Patients in the study group showed significantly higher levels of saliva IL‐1 β , IL‐6, and IL‐17 than those in the control group, and their saliva miR‐23a and miR‐146a were positively correlated with their saliva IL‐1 β , IL‐6, and IL‐17, respectively. Conclusion . Saliva miR‐23a and miR‐146a can be used as biomarkers for the diagnosis and assessment of periodontitis, and they may have regulatory relationships with IL‐1 β , IL‐6, and IL‐17.