Development of electrospun, biomimetic tympanic membrane implants with tunable mechanical and oscillatory properties for myringoplasty
Lukas Benecke, Zhaoyu Chen, Ines Zeidler-Rentzsch, Max von Witzleben, Matthias Bornitz, Thomas Zahnert, Marcus Neudert, Chokri Cherif, Dilbar Aibibu
Abstract
experiments by performing TM reconstruction in human cadaver temporal bones. The reconstructed TM with SF-PCL blend membranes fully recovered the acoustic vibration when the perforation was smaller than 50%. Furthermore, the handling, medium adhesion and transparency of the developed TM implants were similar to those of human TMs.
Topics & Concepts
ElectrospinningBiomedical engineeringPolycaprolactoneMaterials scienceTympanic Membrane PerforationMembraneMicrofiberPerforationMyringoplastyTympanoplastyComposite materialChemistryPolymerSurgeryBiochemistryPunchingMedicineEar Surgery and Otitis MediaAdvanced Sensor and Energy Harvesting MaterialsSilk-based biomaterials and applications