Levels of β-klotho determine the thermogenic responsiveness of adipose tissues: involvement of the autocrine action of FGF21
Ricardo Moure, Montserrat Cairó, Samantha Morón‐Ros, Tania Quesada‐López, Laura Campderrós, Rubén Cereijo, Álvaro Hernáez, Francesc Villarroya, Marta Giralt
Abstract
Reduced levels of KLB (the obligatory FGF21 co-receptor), as occurring in obesity and type 2 diabetes, reduce the thermogenic responsiveness of adipose tissues in cold-exposed mice. Impaired response to β3-adrenergic activation in brown and beige adipocytes with reduced KLB occurs in a cell-autonomous manner involving an autocrine action of FGF21.
Topics & Concepts
FGF21Autocrine signallingEndocrinologyThermogenesisAdipose tissueInternal medicineReceptorBrown adipose tissueKlothoBiologyFibroblast growth factorMedicineKidneyFibroblast Growth Factor ResearchKruppel-like factors researchBody Contouring and Surgery