A biphenyl inhibitor of eIF4E targeting an internal binding site enables the design of cell-permeable PROTAC-degraders
Patrick D. Fischer, Evangelos Papadopoulos, Jon Dempersmier, Zifu Wang, Radosław P. Nowak, Katherine A. Donovan, Joann Kalabathula, Christoph Gorgulla, Pierre Junghanns, Eihab Kabha, Nikolaos Dimitrakakis, Ognyan Petrov, Constantine S. Mitsiades, Christian Ducho, Vladimir Gelev, Eric S. Fischer, Gerhard Wagner, Haribabu Arthanari
Topics & Concepts
EIF4GEIF4EProteolysisChemistryEukaryotic translationCell biologyPlasma protein bindingTranslation (biology)BiochemistryBiologyMessenger RNAGeneEnzymeProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsUbiquitin and proteasome pathways