Photochemical C–H arylation of heteroarenes for DNA-encoded library synthesis
Matthias Krumb, Lisa Marie Kammer, Shorouk O. Badir, María Jesús Cabrera‐Afonso, Victoria E. Wu, Minxue Huang, Adam Csakai, Lisa A. Marcaurelle, Gary A. Molander
Abstract
the photoreduction of DNA-conjugated (hetero)aryl halides to deliver reactive aryl radical intermediates in a regulated fashion within minutes of blue light illumination. A broad array of electron-rich and electron-poor heteroarene scaffolds undergo transformation in the presence of sensitive functional groups.
Topics & Concepts
DNAChemistryCombinatorial chemistryPhotochemistryComputational biologyBiologyBiochemistryRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSynthesis of Indole Derivatives