Photochemical difluoromethylation of alkynes: synthesis of CF<sub>2</sub>H-substituted seven-membered dioxodibenzothiazepines and dibenzazepines
Xiaoyu Chen, Yang Geng, Bo Liu, Yu Zhu, Dapeng Zou, Yangjie Wu, Yusheng Wu
Abstract
A general and efficient photochemical strategy for difluoromethylation/radical cascade cyclization of alkynes with sodium difluoromethylsulfinate (NaSO 2 CF 2 H) has been disclosed.
Topics & Concepts
ChemistryCascadeMedicinal chemistryCombinatorial chemistrySodiumPhotochemistryOrganic chemistryChromatographyFluorine in Organic ChemistrySulfur-Based Synthesis TechniquesRadical Photochemical Reactions