Engineered AAV8 capsid acquires heparin and AVB sepharose binding capacity but has altered in vivo transduction efficiency
Laura P. van Lieshout, Ashley A. Stegelmeier, Tara N. Rindler, John J. Lawder, Debra L. Sorensen, Kathy L. Frost, Stephanie A. Booth, James P. Bridges, Sarah K. Wootton
Topics & Concepts
CapsidTransduction (biophysics)In vivoSepharoseAffinity chromatographyBiologyHeparan sulfateMolecular biologyRecombinant DNAMutantIn vitroBiochemistryHeparinCell biologyGeneEnzymeBiotechnologyVirus-based gene therapy researchHerpesvirus Infections and TreatmentsViral Infectious Diseases and Gene Expression in Insects