Three New Hydroxyphenylacetic Acid Derivatives and A New Alkaloid from Endophytic Fungus <i>Mortierella</i> sp. in <i>Epimedium acuminatum</i> Franch. and Their Antibacterial Activity
Ze‐Diao Huang, Wenjing Wang, Xiaole Han, Xiao‐Long Yang
Abstract
Three new hydroxyphenylacetic acid derivatives, stachylines E-G (1-3), and a new alkaloid, mortieridinone (4), along with six known compounds (5-10), were isolated from endophytic fungus Mortierella sp. in Epimedium acuminatum Franch. Their structures were determined by their spectroscopic analyses and by comparison with the literature data. Compounds 7 and 10 showed selective antibacterial activity against tested multidrug-resistant bacteria with minimum inhibitory concentration (MIC) values ranging from 25 to 3.13 μg/mL.
Topics & Concepts
AlkaloidChemistryAntibacterial activityFungusMinimum inhibitory concentrationTraditional medicineStereochemistryAntimicrobialBacteriaBotanyOrganic chemistryBiologyMedicineGeneticsMedicinal Plant Pharmacodynamics ResearchMicrobial Natural Products and BiosynthesisFungal Biology and Applications