Fabrication of aptamer-guided siRNA loaded lipopolyplexes for gene silencing of notch 1 in MDA-mb-231 triple negative breast cancer cell line
Lobna Gharaibeh, Walhan Alshaer, Suha Wehaibi, Rula Al Buqain, Dana A. Alqudah, Abdulfattah Al-Kadash, Hafsa Al-Azzawi, Abdalla Awidi, Yasser Bustanji
Topics & Concepts
LiposomeAptamerGene silencingCationic liposomeSmall interfering RNATriple-negative breast cancerChemistryBiophysicsCancer cellRNA interferenceCancer researchMaterials scienceMolecular biologyCancerBreast cancerGenetic enhancementBiochemistryBiologyTransfectionRNAGeneGeneticsAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliveryMicroRNA in disease regulation