Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers
Julien Cohen‐Adad, Eva Alonso‐Ortiz, Mihael Abramovic, Carina Arneitz, Nicole Atcheson, Laura Barlow, Robert Barry, Markus Barth, Marco Battiston, Christian Büchel, Matthew D. Budde, Virginie Callot, Anna Combes, Benjamin De Leener, Maxime Descoteaux, Paulo Loureiro de Sousa, Marek Dostál, Julien Doyon, Adam Dvorak, Falk Eippert, Karla R. Epperson, Kevin Epperson, Patrick Freund, Jürgen Finsterbusch, Alexandru Foias, Michela Fratini, Issei Fukunaga, Claudia A. M. Gandini Wheeler‐Kingshott, Giancarlo Germani, Guillaume Gilbert, Federico Giove, Charley Gros, Francesco Grussu, Akifumi Hagiwara, Pierre‐Gilles Henry, Tomáš Horák, Masaaki Hori, James M. Joers, Kouhei Kamiya, Haleh Karbasforoushan, Miloš Keřkovský, Ali Khatibi, Joo-Won Kim, Nawal Kinany, Hagen H. Kitzler, Shannon Kolind, Yazhuo Kong, Petr Kudlička, Paul Kuntke, Nyoman D. Kurniawan, Sławomir Kuśmia, René Labounek, Maria Marcella Laganà, Cornelia Laule, Christine Law, Christophe Lenglet, Tobias Leutritz, Yaou Liu, Sara Llufriú, Sean Mackey, Eloy Martínez‐Heras, Loan Mattera, Igor Nestrašil, Kristin P. O’Grady, Nico Papinutto, Daniel S. Papp, Deborah Pareto, Todd B. Parrish, Anna Pichiecchio, Ferrán Prados, Àlex Rovira, Marc J. Ruitenberg, Rebecca S. Samson, Giovanni Savini, Maryam Seif, Alan C. Seifert, Alex K. Smith, Seth A. Smith, Zachary A. Smith, Elisabeth Solana, Yuichi Suzuki, George Tackley, Alexandra Tinnermann, Jan Valošek, Dimitri Van De Ville, Marios Yiannakas, Kenneth A. Weber, Nikolaus Weiskopf, Richard G. Wise, Patrik O. Wyss, Junqian Xu
Abstract
In a companion paper by Cohen-Adad et al. we introduce the spine generic quantitative MRI protocol that provides valuable metrics for assessing spinal cord macrostructural and microstructural integrity. This protocol was used to acquire a single subject dataset across 19 centers and a multi-subject dataset across 42 centers (for a total of 260 participants), spanning the three main MRI manufacturers: GE, Philips and Siemens. Both datasets are publicly available via git-annex. Data were analysed using the Spinal Cord Toolbox to produce normative values as well as inter/intra-site and inter/intra-manufacturer statistics. Reproducibility for the spine generic protocol was high across sites and manufacturers, with an average inter-site coefficient of variation of less than 5% for all the metrics. Full documentation and results can be found at https://spine-generic.rtfd.io/ . The datasets and analysis pipeline will help pave the way towards accessible and reproducible quantitative MRI in the spinal cord.