Charge Regulation during Amyloid Formation of α-Synuclein
Tinna Pálmadóttir, Anders Malmendal, Thom Leiding, Mikael Lund, Sara Linse
Abstract
values of the acidic residues. We conclude that the proton uptake during the fibril formation is connected to the high density of acidic residues in the C-terminal tail of α-synuclein.
Topics & Concepts
ChemistryAmyloid (mycology)Amyloid βCharge (physics)BiophysicsInternal medicineDiseaseInorganic chemistryMedicineQuantum mechanicsBiologyPhysicsParkinson's Disease Mechanisms and TreatmentsNeurological disorders and treatmentsAlzheimer's disease research and treatments