<i>In situ</i>oxidative polymerization of platinum(<scp>iv</scp>) prodrugs in pore-confined spaces of CaCO<sub>3</sub>nanoparticles for cancer chemoimmunotherapy
Fangmian Wei, Libing Ke, Siyuan Gao, Johannes Karges, Jinquan Wang, Yu Chen, Liangnian Ji, Hui Chao
Abstract
Pt(iv)SS@CaCO3@Biotin can interact in cisplatin-resistant non-small lung cancer cells by a multimodal mechanism of action, triggering cell death by a combination of by apoptosis, ferroptosis, and immunogenic cell death in vitro and in vivo .
Topics & Concepts
ChemistryCisplatinProgrammed cell deathReactive oxygen speciesIn vivoProdrugApoptosisCancer cellBiophysicsCancer researchCancerBiochemistryChemotherapyMedicineBiologySurgeryBiotechnologyInternal medicineNanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisMetal-Organic Frameworks: Synthesis and Applications