Synthesis and in vitro Antidiabetic Screening of Novel Dihydropyrimidine Derivatives
Jaydeep Lalpara, M. D. Vachhani, Sanjay Hadiyal, Swati Goswami, G. G. Dubal
Abstract
Abstract A series of N-substituted-6-methyl-4-{4-[5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl]methoxyphenyl}-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamides have been synthesized by the condensation of newly synthesized {4-[5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl]methoxy}benzaldehyde with variously substituted acetoacetanilides and urea in the presence of ethanol. The synthesized compounds have been characterized by 1H, 13C NMR, IR spectroscopy, and mass spectrometry. All synthesized compounds were evaluated for in vitro antidiabetic activity using the α-amylase inhibition assay with the 3,5-dinitrosalicylic acid (DNSA) reagent.
Topics & Concepts
ChemistryBenzaldehydeEthanolIn vitroReagentCondensationUreaOrganic chemistryMass spectrometryNuclear chemistryCatalysisChromatographyBiochemistryPhysicsThermodynamicsSynthesis and biological activityMulticomponent Synthesis of HeterocyclesQuinazolinone synthesis and applications