An RNAi therapeutic targeting hepatic DGAT2 in a genetically obese mouse model of nonalcoholic steatohepatitis
Batuhan Yenilmez, Nicole Wetoska, Mark Kelly, Dimas Echeverria, Kyounghee Min, Lawrence M. Lifshitz, Julia F. Alterman, Matthew Hassler, Samuel Hildebrand, Chloe DiMarzio, Nicholas McHugh, Lorenc Vangjeli, Jacquelyn Sousa, Meixia Pan, Xianlin Han, Michael A. Brehm, Anastasia Khvorova, Michael Czech
Topics & Concepts
Nonalcoholic steatohepatitisSteatohepatitisRNA interferenceBiologyGenetically modified organismMedicineCancer researchGeneNonalcoholic fatty liver diseaseInternal medicineFatty liverGeneticsRNADiseaseLiver Disease Diagnosis and TreatmentEndoplasmic Reticulum Stress and DiseaseLipid metabolism and biosynthesis