5-Aminosalicylic Acid Ameliorates Colitis and Checks Dysbiotic Escherichia coli Expansion by Activating PPAR-γ Signaling in the Intestinal Epithelium
Stephanie A. Cevallos, Jee‐Yon Lee, Eric M. Velazquez, Nora J. Foegeding, Catherine Shelton, Connor R. Tiffany, Beau H. Parry, Annica R. Stull-Lane, Erin E. Olsan, Hannah P. Savage, Henry Nguyen, Star S. Ghanaat, Austin J. Byndloss, Ilechukwu Agu, Renée M. Tsolis, Mariana X. Byndloss, Andreas J. Bäumler
Abstract
An expansion of Enterobacterales in the fecal microbiota is a microbial signature of dysbiosis that is linked to many noncommunicable diseases, including ulcerative colitis. Here, we used Escherichia coli , a representative of the Enterobacterales , to show that its dysbiotic expansion during colitis can be remediated by modulating host epithelial metabolism.
Topics & Concepts
Aminosalicylic acidEscherichia coliMicrobiologyIntestinal epitheliumColitisEpitheliumChemistryMedicineBiologyPharmacologyBiochemistryImmunologyPathologyGeneGut microbiota and healthHelicobacter pylori-related gastroenterology studiesClostridium difficile and Clostridium perfringens research