Nuclear translocation of thioredoxin-1 promotes colorectal cancer development via modulation of the IL-6/STAT3 signaling axis through interaction with STAT3
Aihua Wu, Daoquan Fang, Yangyang Liu, Xiaomeng Shi, Zuyue Zhong, Baojian Zhou, Lechi Ye, Xuecheng Sun, Lei Jiang
Abstract
These results provide new insights into the mechanisms of STAT3 activation triggered by IL-6 and identify nuclear translocation of Trx-1 as a potential therapeutic target for the treatment of CRC and CAC.
Topics & Concepts
Cancer researchKaryopherinColorectal cancerBiologyChromosomal translocationMolecular biologyThioredoxinChemistryCancerCell nucleusNuclear transportCell biologyCytoplasmOxidative stressBiochemistryGeneGeneticsRedox biology and oxidative stressCytokine Signaling Pathways and InteractionsGDF15 and Related Biomarkers