Dual target PARP1/EZH2 inhibitors inducing excessive autophagy and producing synthetic lethality for triple-negative breast cancer therapy
Xinxin Li, Cheng Wang, Shang Li, Fucheng Yin, Heng Luo, Yonglei Zhang, Zhongwen Luo, Yifan Chen, Siyuan Wan, Lingyi Kong, Xiaobing Wang, Xiaobing Wang
Topics & Concepts
Synthetic lethalityTriple-negative breast cancerPARP1EZH2Cancer researchBreast cancerChemistryIC50Poly ADP ribose polymeraseCancerAutophagyMedicineIn vitroInternal medicineDNA repairEpigeneticsApoptosisEnzymeBiochemistryGenePolymerasePARP inhibition in cancer therapyCRISPR and Genetic EngineeringDNA Repair Mechanisms