Diosmin, a citrus fruit-derived phlebotonic bioflavonoid protects rats from chronic kidney disease-induced loss of bone mass and strength without deteriorating the renal function
Shivani Sharma, Konica Porwal, Chirag Kulkarni, Subhashis Pal, Praveer Sihota, Saroj Kumar, Mahesh Chandra Tiwari, Roshan Katekar, Ashish Kumar, Priya Singh, Swati Rajput, Rajdeep Guha, Navin Kumar, Jiaur R. Gayen, Naibedya Chattopadhyay
Abstract
) protected against CKD-induced bone loss. These data suggest that diosmin and its metabolic surrogate, diosmetin protect against CKD-induced osteopenia. Since diosmin has no renal adverse effect and protected bone mass and strength in CKD rats, we propose assessing its anti-osteoporosis effect in CKD patients.
Topics & Concepts
DiosminMedicineKidney diseaseOsteoporosisUrologyInternal medicineEndocrinologyRenal functionPathologyHesperidinAlternative medicineParathyroid Disorders and TreatmentsBone Metabolism and DiseasesBone health and treatments