Mechanochemical Solvent‐Free Catalytic C−H Methylation
Shengjun Ni, Matic Hribersek, Swarna K. Baddigam, Fredric J. L. Ingner, Andreas Orthaber, Paul J. Gates, Lukasz T. Pilarski
Abstract
The mechanochemical, solvent-free, highly regioselective, rhodium-catalyzed C-H methylation of (hetero)arenes is reported. The reaction shows excellent functional-group compatibility and is demonstrated to work for the late-stage C-H methylation of biologically active compounds. The method requires no external heating and benefits from considerably shorter reaction times than previous solution-based C-H methylation protocols. Additionally, the mechanochemical approach is shown to enable the efficient synthesis of organometallic complexes that are difficult to generate conventionally.
Topics & Concepts
MethylationCatalysisRegioselectivityRhodiumChemistryCombinatorial chemistrySolventCompatibility (geochemistry)Organic chemistryMaterials scienceBiochemistryGeneComposite materialCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsCarbon dioxide utilization in catalysis