Co(<scp>iii</scp>)-catalyzed regioselective benzannulation of substituted pyridones with 1,6-diynes <i>via</i> dual C–H bond activation
Suresh Kumar Yadav, Masilamani Jeganmohan
Abstract
dual C-H bond activation has been reported. The scope of the benzannulation reaction was examined with various substituted 2-pyridyl pyridones and 1,6-diynes. The combination of cuprous acetate and silver carbonate plays a crucial role in the success of the reaction. A plausible reaction mechanism was proposed and supported by deuterium labelling studies and radical trapping experiments.
Topics & Concepts
RegioselectivityCatalysisChemistryMedicinal chemistryDual roleDual (grammatical number)Scope (computer science)Combinatorial chemistryOrganic chemistryLiteratureProgramming languageComputer scienceArtCatalytic C–H Functionalization MethodsSynthesis of Indole DerivativesCatalytic Alkyne Reactions