COVID-19 in an immunocompromised host: persistent shedding of viable SARS-CoV-2 and emergence of multiple mutations: a case report
Wayne Leung, Samuel D. Chorlton, John R. Tyson, Ghada N. Al‐Rawahi, Agatha N. Jassem, Natalie Prystajecky, Shazia Masud, Gregory D. Deans, Michael Chapman, Yazdan Mirzanejad, Melanie C. M. Murray, Patrick Wong
Abstract
This article reports a case of a 21-year-old woman with refractory B-cell acute lymphocytic leukaemia who presented with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). She remained positive for SARS-CoV-2 by viral culture for 78 days and by polymerase chain reaction (PCR) for 97 days. Sequencing of repeat samples over time demonstrated an increasing and dynamic repertoire of mutations.
Topics & Concepts
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)VirologyPolymerase chain reactionViral shedding2019-20 coronavirus outbreakCoronavirusBiologyMutationRespiratory systemImmunologyMedicineGeneVirusGeneticsPathologyOutbreakDiseaseInfectious disease (medical specialty)AnatomySARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesImmunodeficiency and Autoimmune Disorders