The Promises and Limitations of <i>N</i> -Acetylcysteine as a Potentiator of First-Line and Second-Line Tuberculosis Drugs
Catherine Vilchèze, William R. Jacobs
Abstract
-infected mice, the addition of NAC did not augment the activity of first- or second-line TB drugs. A comparison of the activity of NAC combined with TB drugs in murine and human macrophage cell lines revealed that studies in mice might not be recapitulated during host infection in vivo.
Topics & Concepts
PotentiatorAcetylcysteineTuberculosisFirst lineSecond lineLine (geometry)MedicinePharmacologyChemistryInternal medicinePathologyMathematicsBiochemistryGeometryAntioxidantTuberculosis Research and EpidemiologyPneumocystis jirovecii pneumonia detection and treatmentHIV/AIDS drug development and treatment