“Gear-driven”-type chirality transfer of tetraphenylethene-based supramolecular organic frameworks for peptides in water
Chaochao Yan, Qingfang Li, Kaige Wang, Wanni Yang, Jingyu Han, Yawen Li, Yunhong Dong, Dake Chu, Lin Cheng, Liping Cao
Abstract
-rotational conformation, exhibiting significantly different circular dichroism (CD) spectra. Although various peptides have the same l-type chiral configuration, they can induce positive CD signals of SOF-1 and negative CD signals of SOF-2 and SOF-3, respectively. Based on the structural analysis of the linkage units between CB[8] and TPE units in these SOFs, a "gear-driven"-type chirality transfer mechanism has been proposed to visually illustrate the multiple-step chirality transfer process from the recognition site in the CB[8]'s cavity to TPE units. Furthermore, by utilizing the characteristic CD signals generated through the "gear-driven"-type chirality transfer, these SOFs can serve as chiroptical sensor arrays to effectively recognize and distinguish various peptides based on their distinctive CD spectra.