Phenoxy pendant isatins as potent α-glucosidase inhibitors: reciprocal carbonyl⋯carbonyl interactions, antiparallel π⋯π stacking driven solid state self-assembly and biological evaluation
Saba Mehreen, Mehwash Zia, Ajmal Khan, Javid Hussain, Saeed Ullah, Muhammad U. Anwar, Ahmed Al‐Harrasi, Muhammad Moazzam Naseer
Abstract
= 873.34 ± 1.67). Easy access and high α-glucosidase inhibition potential of these phenoxy pendant isatins 1-12 provide an attractive platform for finding more effective medication for controlling postprandial hyperglycemia.
Topics & Concepts
Antiparallel (mathematics)StackingChemistrySolid-stateCarbonyl groupStereochemistryCrystallographyComputational chemistryOrganic chemistryPhysical chemistryPhysicsMagnetic fieldQuantum mechanicsCarbohydrate Chemistry and SynthesisSeaweed-derived Bioactive CompoundsSynthesis and biological activity