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KDM4A regulates the maternal-to-zygotic transition by protecting broad H3K4me3 domains from H3K9me3 invasion in oocytes

Aditya Sankar, Mads Lerdrup, Adeel Manaf, Jens Vilstrup Johansen, Javier Martín‐González, Rehannah Borup, Robert Blanshard, Arne Klungland, Klaus Hansen, Claus Yding Andersen, John Arne Dahl, Kristian Helin, Eva R. Hoffmann

2020Nature Cell Biology128 citationsDOIOpen Access PDF

Topics & Concepts

H3K4me3Maternal to zygotic transitionBiologyDemethylaseCell biologyEpigenomeEpigeneticsHistone H3HistoneGeneticsZygoteEmbryogenesisDNA methylationEmbryoGene expressionGenePromoterEpigenetics and DNA MethylationReproductive Biology and FertilityGenomics and Chromatin Dynamics
KDM4A regulates the maternal-to-zygotic transition by protecting broad H3K4me3 domains from H3K9me3 invasion in oocytes | Litcius