Dictated Emergence of Nucleic Acid-Based Constitutional Dynamic Networks by DNA Replication Machineries
Zhixin Zhou, Jianbang Wang, Itamar Willner
Abstract
, to the selective emergence of two different [2 × 2] CDNs or to a [3 × 3] CDN. Also, a set of six appropriately engineered template/blocker scaffolds, coupled to the polymerase/dNTP machinery, leads to the emergence of a CDN composed of four equilibrated DNA tetrahedra constituents. Finally, by further sequence engineering of the set of template/blocker scaffolds and their coupling to a nicking/polymerization/dNTP replication machinery, the amplified high-throughput emergence of CDNs is demonstrated.
Topics & Concepts
ChemistryNucleic acidPrimer (cosmetics)PolymeraseDNA replicationDNAComputational biologyDNA polymeraseCombinatorial chemistryBiophysicsBiochemistryBiologyOrganic chemistryAdvanced biosensing and bioanalysis techniquesDNA and Nucleic Acid ChemistryDNA and Biological Computing