Transforming “cold” tumors into “hot” ones <i>via</i> immunogenic cell death by bufadienolides for reverse immunosuppressive TME in HCC
Xin Qiao, Pei Ma, Jueshuo Guo, Yongkun Sun, Peng Li, Na Yu, Wenbao Zuo, Jianhong Yang
Abstract
"inactivated vaccine" to effectively enhance the ability of mice to resist the challenge of a live tumor. Our study demonstrates a promising strategy for remodeling the immunosuppressive TME of liver cancer.
Topics & Concepts
Hepatocellular carcinomaTumor microenvironmentImmunogenic cell deathCancer researchMedicineCancerTumor cellsImmunologyImmune systemImmunotherapyInternal medicineImmune Cell Function and InteractionImmune Response and InflammationImmune cells in cancer