Androgen receptor suppresses lung cancer invasion and increases cisplatin response <i>via</i> decreasing TPD52 expression
Shiqing Liu, Chengping Hu, Min Li, Wolong Zhou, Ronghao Wang, Yao Xiao
Abstract
data also validated the functional contribution of AR/circ-SLCO1B7/miR-139-5p/TPD52 axis to lung cancer progression. Furthermore, analysis of human NSCLC databases and clinical specimens confirmed the association of the AR/circ-SLCO1B7/miR-139-5p/TPD52 signaling pathway with NSCLC progression. Collectively, the results from our study suggest that AR can suppress lung cancer cell invasion and increase DDP response by modulating the circ-SLCO1B7/miR-139-5p/TPD52 signaling pathway. Targeting this novel signaling pathway may be a new therapeutic strategy to effectively constrain NSCLC development.
Topics & Concepts
Lung cancerAndrogen receptorCancer researchCisplatinGene silencingUntranslated regionMalignancyBiologyCancerMessenger RNAInternal medicineOncologyMedicineGeneProstate cancerChemotherapyGeneticsCircular RNAs in diseasesCancer-related molecular mechanisms research